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Human-in-the Loop

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Parashar Biswas Sr. General Manager-Projects| Viatris Bangalore, Karnataka, India
What is the Broader definition of Human-in-the-Loop ? Any specific guideline ?
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Luis Branco CEO| Business Insight, Consultores de Gestão, Ldª Carcavelos, Lisboa, Portugal

Parashar Biswas
Human-in-the-Loop (HITL) broadly refers to systems or processes where human intervention is intentionally integrated into one or more stages of an automated or AI-driven workflow, especially in areas requiring judgment, correction, oversight, or ethical discernment.

In practice, HITL involves human participation in key phases such as data preparation, model training, validation of outputs, continuous feedback, and exception handling.
This ensures not only better performance and quality, but also ethical accountability and adaptability in complex or high-stakes contexts.

There are well-established guidelines for implementing Human-in-the-Loop systems responsibly, including:

- When to involve human judgment (e.g., critical decisions, ambiguous cases, ethical dilemmas)

- How to manage feedback loops between human reviewers and automated systems, allowing learning and adaptation

- How to document and audit decisions to ensure traceability, compliance, and accountability

- Who should be involved, ensuring domain expertise and clear roles in the HITL process

- How to mitigate bias and maintain fairness, especially when AI is involved in human-impacting decisions

- How to balance automation and oversight using human input where it adds real value

- How to design interfaces and workflows that make it easy for humans to review, adjust, or override system outputs

These practices are increasingly reflected in international standards (like ISO/IEC 42001, OECD AI Principles, and NIST frameworks) and can be adapted to various domains, including project environments and strategic decision-making processes.

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1 reply by Parashar Biswas
Sep 22, 2025 8:07 AM
Parashar Biswas
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Appreciate Luis , for your nice elaboration on HITL. Thanks and it is very helpful indeed.
Regards,
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Kiron Bondale Retired | Mentor| Retired Welland, Ontario, Canada
Parashar -

The term is usually used to denote the value in having a skilled, competent human being involved in a transaction or process which has been mostly automated to audit, assess and fine tune the automation.

Depending on the level of criticality of the outputs, how opaque the automation decision making is, and the likelihood of false positives or false negatives, there might need to be less or more involvement.

Kiron
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1 reply by Parashar Biswas
Sep 19, 2025 8:19 AM
Parashar Biswas
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Not convinced . Because I am asking specific HITL application in AI/ML in Pharma world.

Parashar
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Parashar Biswas Sr. General Manager-Projects| Viatris Bangalore, Karnataka, India
Sep 19, 2025 7:19 AM
Replying to Kiron Bondale
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Parashar -

The term is usually used to denote the value in having a skilled, competent human being involved in a transaction or process which has been mostly automated to audit, assess and fine tune the automation.

Depending on the level of criticality of the outputs, how opaque the automation decision making is, and the likelihood of false positives or false negatives, there might need to be less or more involvement.

Kiron
Not convinced . Because I am asking specific HITL application in AI/ML in Pharma world.

Parashar
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1 reply by Kiron Bondale
Sep 19, 2025 1:03 PM
Kiron Bondale
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Sorry - "not convinced"? Of what? The value of HITL?

Pharma is a great example of an industry where blindly trusting AI/ML is extremely risky when you look at the significant costs involved with bringing drugs to market. Without subject matter experts validating the inputs, methodology and outputs of a learning model the risk of not getting through the validation process would be high.

Kiron
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Pavan Maddi
Community Champion
Buona Vista, Singapore

Human-in-the-Loop (HITL) generally means systems where people stay actively involved in decision-making, monitoring, or corrections, especially when AI or automation is used. It ensures accountability, ethical checks, and context judgment that machines can’t fully provide. No single guideline exists, but common principles are: keep humans in control of critical decisions, design for transparency, and define clear escalation points.

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Kiron Bondale Retired | Mentor| Retired Welland, Ontario, Canada
Sep 19, 2025 8:19 AM
Replying to Parashar Biswas
...
Not convinced . Because I am asking specific HITL application in AI/ML in Pharma world.

Parashar
Sorry - "not convinced"? Of what? The value of HITL?

Pharma is a great example of an industry where blindly trusting AI/ML is extremely risky when you look at the significant costs involved with bringing drugs to market. Without subject matter experts validating the inputs, methodology and outputs of a learning model the risk of not getting through the validation process would be high.

Kiron
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Sergio Luis Conte Helping to create solutions for everyone| Worldwide based Organizations Buenos Aires, Argentina
If you are talking about IA it is mainly related about all results are probabilistic and the human being must decide about the results. Depending on the process you use and the outcomes needed the human being must participate in some steps to take decisions. Mainly if you are using generative AI. So, human in the loop is related to human being intervention and accountability about the decisions.
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Parashar Biswas Sr. General Manager-Projects| Viatris Bangalore, Karnataka, India
Thanks to all for commenting on HITL.
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Parashar Biswas Sr. General Manager-Projects| Viatris Bangalore, Karnataka, India
Sep 19, 2025 5:08 AM
Replying to Luis Branco
...

Parashar Biswas
Human-in-the-Loop (HITL) broadly refers to systems or processes where human intervention is intentionally integrated into one or more stages of an automated or AI-driven workflow, especially in areas requiring judgment, correction, oversight, or ethical discernment.

In practice, HITL involves human participation in key phases such as data preparation, model training, validation of outputs, continuous feedback, and exception handling.
This ensures not only better performance and quality, but also ethical accountability and adaptability in complex or high-stakes contexts.

There are well-established guidelines for implementing Human-in-the-Loop systems responsibly, including:

- When to involve human judgment (e.g., critical decisions, ambiguous cases, ethical dilemmas)

- How to manage feedback loops between human reviewers and automated systems, allowing learning and adaptation

- How to document and audit decisions to ensure traceability, compliance, and accountability

- Who should be involved, ensuring domain expertise and clear roles in the HITL process

- How to mitigate bias and maintain fairness, especially when AI is involved in human-impacting decisions

- How to balance automation and oversight using human input where it adds real value

- How to design interfaces and workflows that make it easy for humans to review, adjust, or override system outputs

These practices are increasingly reflected in international standards (like ISO/IEC 42001, OECD AI Principles, and NIST frameworks) and can be adapted to various domains, including project environments and strategic decision-making processes.

Appreciate Luis , for your nice elaboration on HITL. Thanks and it is very helpful indeed.
Regards,

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