Check Out The Niche Stuff Before Deciding...

Situation: Your need PM Software for some unusual project challenges 

Most of us looking for project management software limit our range of choices to the big names.  Whether or not we end up choosing a big name or highly specialized package, its a good idea to look at the niche offerings.  They may not end up being what you need, or integrate well with your other efforts - but giving them a look will likely refine your thinking about your unique needs.

For example, consider RoboHead marketing project management software (think highly repeatable best practices, short and simple projects).  These guys could care less about gantt charts, dependencies, etc.  Workflow, document management, integrated reviews REALLY matter a lot in this context.  Once you've taken the tour here, it makes you look at MS Project in a whole different light. 

ATC Professional project management software is incredibly specific - designed for dealing with industrial plant projects.  These projects are non-stop, complex efforts that require very detailed tracking not only of progress, but effort and compliance with government regulations. 

This may sound like a simple thing, but many people never think of Googling "[project type] + Project Management".  That's likely to be your best first step on the road to understand what your specific needs are.